Investigation of alkaline phosphatase activity and obesity as biological markers in asthma patients in Babylon governorate

Background: Asthma inflammation results from the activation of several components that generate pro-inflammatory cytokines. Corticosteroid therapy can affect bone formation by altering the activity of the alkaline phosphatase enzyme. Although the causes of this link are unclear, obesity is also a significant risk factor for developing asthma. It is thought that inflammatory alterations in adipose tissue may cause increased airway inflammation and responsiveness in obese people.
Objectives: This study aimed to evaluate an increase in alkaline phosphatase due to inflammatory events and study the effects of obesity on asthma.
Patients and methods: There were one hundred participants in this case-control study. The blood samples were collected from the allergy and asthma center in Hilla City and split into two groups: the control group and the patient group, which had asthma symptoms. 
Result: Significant gender differences were observed in the asthma group, which had a higher proportion of women than men. Regarding the relationship between asthma and blood group, our result showed that among patients with asthma, the A+ group was the most common blood group by 35%. For body mass index results, it was noted that individuals who are obese are more prone to asthma. Serum alkaline phosphatase activity was found to be significantly higher in the asthmatic groups than in healthy controls.
Conclusion: This study found significant gender differences in asthma prevalence, with more women affected than men. Severity levels were higher than the global average of 5%, and the severe category had the fewest cases. Asthma was more common in individuals with A+ blood type, and obese individuals showed significantly higher rates of asthma. Notably, obese women had higher asthma rates than obese men. Additionally, serum alkaline phosphatase activity was raised considerably in asthmatic participants compared to healthy controls.