Department of Pharmacy Practice, E.G.S. Pillay College of Pharmacy, Nagapattinam, Tamil Nadu, India.
International Journal of Science and Research Archive, 2025, 17(01), 330-336
Article DOI: 10.30574/ijsra.2025.17.1.2736
Received on 23 August 2025; revised on 06 October 2025; accepted on 08 October 2025
Background: Tuberculosis (TB) continues to be a major health problem in India. Multi-drug resistant TB (MDR-TB) creates significant challenges for treatment.
Methods: A retrospective study took place at Government Medical College Hospital in the Southern Coastal Region of Tamil Nadu. It involved 350 patients (250 with pulmonary TB and extra-pulmonary TB, and 100 with MDR-TB) between 2023 and 2024. We analyzed data on demographics, risk factors, treatment plans, and outcomes.
Results: Among the 350 patients, 60% were male, most aged 21 to 40 years. Pulmonary TB made up 65% of cases, extra-pulmonary TB 35%, and MDR-TB accounted for 28.6%. Common risk factors included malnutrition, smoking, HIV, and diabetes. The success rate for treatment was 78% for drug-sensitive TB and 62% for MDR-TB, with higher mortality in MDR-TB cases.
Conclusion: Standard treatment plans are effective for pulmonary and extra-pulmonary TB, but the results for MDR-TB are still poor. Early drug sensitivity testing, better adherence to treatment, and access to newer regimens are essential for improving outcomes.
Tuberculosis; MDR-TB; Prescribing patterns; Outcomes
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M. Selvamuthu, M. Santhana Kumar, M. Naveenkumar, M. Mathesh, S. Vignesh and V. Vignesh. A retrospective cohort study of drug-sensitive and MDR-tuberculosis outcomes in southern coastal Tamil Nadu. International Journal of Science and Research Archive, 2025, 17(01), 330-336. Article DOI: https://doi.org/10.30574/ijsra.2025.17.1.2736.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
