1 Department of Pharmacy, University clinical hospital“Lozano Blesa”, Zaragoza, Spain.
2 Unit for the Rational Use of Medicines, Aragon Health Service, Zaragoza, Spain.
International Journal of Science and Research Archive, 2025, 16(03), 1342-1346
Article DOI: 10.30574/ijsra.2025.16.3.2740
Received on 23 August 2025; revised on 28 September 2025; accepted on 30 September 2025
Objective: To analyze the association between chronic lithium treatment and selective immunoglobulin deficiency, exploring pathophysiological mechanisms, clinical consequences, and monitoring strategies.
Methods: Observational data from patients on long-term lithium therapy were combined with a review of the literature.
Results: Lithium exposure was associated with reductions in immunoglobulin levels, particularly IgG and IgA, predisposing to recurrent infections and altered immune responses.
Conclusion: Immunoglobulin deficiency should be considered an underrecognized complication of lithium therapy, requiring routine immunological monitoring and individualized management strategies.
Lithium; Immunoglobulin Deficiency; Bipolar Disorder; Immunology; Adverse Drug Reactions
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Roberto Lozano and Carina Bona. Selective Immunoglobulin Deficiency in Patients Treated with Lithium: Clinical and Immunological Insights. International Journal of Science and Research Archive, 2025, 16(03), 1342-1346. Article DOI: https://doi.org/10.30574/ijsra.2025.16.3.2740.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
