CHD2 Protein Malfunction Causing Neurodevelopmental Disorders and Epilepsy as Analyzed by Resonant Recognition Model

Mutations in CHD2 gene are strongly associated with developmental and epileptic encephalopathy, characterized by early-onset, drug-resistant seizures and neurodevelopmental impairments. In response to the urgent need for novel interventions, we have utilized here, the Resonance Recognition Model (RRM), a biophysical framework that identifies and targets specific protein resonances associated with these pathological conditions. Our analysis revealed a consistent association between CHD2 protein activity and a specific far-infrared resonance, at RRM frequency of 0.0005 corresponding to wavelength of 0.2 to 0.4mm, suggesting that lack of this frequency (wavelength) may represent a biophysical signature of the dysfunctional protein. Based on these results unveiling resonance signature, we also hypothesize potential therapeutic strategies.