Centro Universitário Alfredo, Goiânia, Goiás.
International Journal of Science and Research Archive, 2025, 16(02), 924-925
Article DOI: 10.30574/ijsra.2025.16.2.2404
Received on 09 July 2025; revised on 16 August 2025; accepted on 18 August 2025
Sensorineural hearing loss (SNHL) remains a significant clinical challenge due to the limited regenerative capacity of cochlear cells in mammals. Recent advancements in gene therapy and stem cell technologies offer promising avenues for cochlear regeneration. This review synthesizes current research on the application of gene therapy and stem cells in cochlear regeneration, focusing on their mechanisms, therapeutic potentials, and clinical implications. We explore the roles of various stem cell types, including mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs), and discuss gene editing strategies aimed at restoring cochlear function. The review also addresses the challenges and future directions in this field, emphasizing the need for further research to translate these therapies into clinical practice.
Cochlea; Gene Therapy; Stem Cells; Cochlear Regeneration; Sensorineural Hearing Loss
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Luiz Antônio Rosa Simão Rodrigues, Igor Diniz Sato, Livia Clair Tolentino e Sousa, Karla Stephanny Alves Silveira, Kamila Noleto Bastos and Artemis Sandra Borges Nunes Costa. Gene therapy and stem cells in cochlear regeneration: A Comprehensive Review. International Journal of Science and Research Archive, 2025, 16(02), 924-925. Article DOI: https://doi.org/10.30574/ijsra.2025.16.2.2404.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
