1 Department of Pharmacy, University clinical hospital“Lozano Blesa”, Zaragoza, Spain.
2 Unit for the Rational Use of Medicines, Aragon Health Service, Zaragoza, Spain.
International Journal of Science and Research Archive, 2025, 16(03), 1334-1337
Article DOI: 10.30574/ijsra.2025.16.3.2738
Received on 23 August 2025; revised on 28 September 2025; accepted on 30 September 2025
Objective: To evaluate the prevalence of folate deficiency in patients presenting with depressive symptoms and to explore associated biochemical abnormalities and clinical implications.
Methods: Observational study analyzing serum folate, vitamin B12, ferritin, thyroid function, and homocysteine levels in patients with depressive symptoms.
Results: Folate deficiency was prevalent in a significant subset of patients and was frequently associated with vitamin B12 deficiency, iron deficiency, and thyroid dysfunction.
Conclusion: Folate deficiency is a common and potentially modifiable factor in depression, underscoring the need for routine biochemical screening in psychiatric care.
Folate deficiency; Depression; Homocysteine; Ferritin; Vitamin B12; Thyroid function
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Roberto Lozano and Carina Bona. Prevalence of Folate Deficiency in Patients with Depressive Symptoms: Biochemical and Clinical Implications. International Journal of Science and Research Archive, 2025, 16(03), 1334-1337. Article DOI: https://doi.org/10.30574/ijsra.2025.16.3.2738.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
