1 Department of Pharmacy, University clinical hospital“Lozano Blesa”, Zaragoza, Spain.
2 Unit for the Rational Use of Medicines, Aragon Health Service, Zaragoza, Spain.
International Journal of Science and Research Archive, 2025, 16(03), 1347-1351
Article DOI: 10.30574/ijsra.2025.16.3.2741
Received on 23 August 2025; revised on 28 September 2025; accepted on 30 September 2025
Objective: To evaluate the prevalence of vitamin B12 deficiency in patients presenting with depressive symptoms and to explore its biochemical and clinical implications. Methods: Observational study assessing serum vitamin B12, folate, ferritin, thyroid function, and homocysteine in patients with depressive symptoms. Results: Vitamin B12 deficiency was identified in a significant proportion of patients, with associated elevations in homocysteine and frequent comorbid deficiencies in ferritin and thyroid dysfunction. Conclusion: Vitamin B12 deficiency is a common yet underrecognized contributor to depressive symptomatology, and routine screening should be integrated into psychiatric evaluations.
Vitamin B12 deficiency; Depression; Homocysteine; Ferritin; Thyroid function
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Roberto Lozano and Carina Bona. Prevalence of Vitamin B12 Deficiency in Patients with Depressive Symptoms: Clinical and Biochemical Correlations. International Journal of Science and Research Archive, 2025, 16(03), 1347-1351. Article DOI: https://doi.org/10.30574/ijsra.2025.16.3.2741.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
