Department of Pharmaceutical Chemistry, Pravara Rural College Of Pharmacy, Loni, Tal. Rahata, Dist. Ahmednagar, Maharashtra, India. Pin- 413736
International Journal of Science and Research Archive, 2025, 14(03), 1282-1290
Article DOI: 10.30574/ijsra.2025.14.3.0778
Received on 13 February 2025; revised on 20 March 2025; accepted on 22 March 2025
The development of novel antifungal agents is therefore urgently needed. Many fungicidal treatments have become ineffective due to development of resistance, a range of undesirable effects, and excess toxicity. Hence, the need to synthesize and develop some sort of new antifungal drugs. 1,2,4-triazole is one of the most important pharmacophore systems of five-membered heterocycles. The nitro-containing heterocycle demonstrated a potential antifungal activity in its structure-activity relationship (SAR).
A wide variety of classes of antifungal agents contain the 1,2,4-triazole core as part of their nucleus. Due to their strongest and broad spectrum activity, triazoles are clinically important moieties. The purpose of this article is to review the advances in the synthesis and SAR of 1,2,4-triazole as a potential fungicide.
1;2;4-triazoles; Antifungal; Synthesis; 1Q6S Receptor; Ethanol; Pharmacology; Fungal
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Amol Sopanrao Dighe, Rohit Dadabhau Bankar and Viraj Bhagwat Bangar. In silico investigation and molecular docking study of 1,2,4-triazole derivatives for antifungal activity. International Journal of Science and Research Archive, 2025, 14(03), 1282-1290. Article DOI: https://doi.org/10.30574/ijsra.2025.14.3.0778.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
