1 Faculty of Medical Sciences, Goce Delcev University, Stip Krste Misirkov bb, 2000 Shtip, Republic of North Macedonia.
2 Clinical Hospital-Stip, Ljuben Ivanov bb, 2000 Shtip, Republic of North Macedonia.
3 Remedika General Hospital Skopje, Republic of North Macedonia 16-ta Makedonska Brigada 18, Skopje 1000.
International Journal of Science and Research Archive, 2025, 14(03), 253-255
Article DOI: 10.30574/ijsra.2025.14.3.0566
Received on 17 January 2025; revised on 27 February 2025; accepted on 02 March 2025
Introduction: Necrobiosis lipoidica is a very rare and chronic disease characterized by yellow-brown, atrophic, telangiectatic changes that occur mostly on the lower extremities. It is characterized by the appearance of collagen necrobiosis and dermal inflammation.
Case report: A 50-year-old patient with changes on both lower legs that date back to a year ago and for which she never sought medical help complains of the appearance of an ulcer two weeks ago on one of the changes after a minor trauma.
Conclusion: Necrobiosis lipoidica is a rare granulomatous disease associated with diabetes and autoimmune diseases that patients have already diagnosed, but in our case the skin changes were the first that led us to additional research and diagnosis of diabetes and rheumatoid arthritis.
Necrobiosis lipoidica; Type 1 diabetes; Rheumatoid arthritis; Autoimmune diseases
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Mirela Vasileva, Lidija Petrovska and Dimitar Spoa. Necrobiosis lipoidica as a cutaneous marker of underlying metabolic and autoimmune disorders: A case report. International Journal of Science and Research Archive, 2025, 14(03), 253-255. Article DOI: https://doi.org/10.30574/ijsra.2025.14.3.0566.
Copyright © 2025 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0
